Jamie Madrox and Monoxide, the mindsick masterminds behind Twiztid, have been in the entrainment business since 1993. They started in a group called House of Krazees and made their imprint in the Detroit music scene. In 1997 they would form Twiztid. Twiztid's music is best explained as a horror movie on CD.

Twiztid signed to Insane Clown Posse's Psychopathic Records in 1997 and released their first album Mostasteless. In 1999 Mostasteless was rereleased through Island/Def Jam. The rerelease of Mostasteless peaked at #8 on the Billboard Heatseekers Chart and #149 on the Billboard 200. Twiztid would go onto headline their own night at the first annual Gathering of the Juggalos, star in the movie Big Money Hustlas, headline their first tour entitled Rock The Dead, release a DVD entitled Born Twiztid, & grace the cover of Alternative Press Magazine along side ICP all before their second studio album Freek Show (October 31, 2000). Freek Show debuted at #51 on the Billboard 200. Twiztid soon hit the road headlining their Freek Show Tour to promote the record.

Since Freek Show, Twiztid have released eight full-length albums all charting on the Billboard 200, plus a maniacal myriad of compilations, collections, EPs, solo albums and side projects. Their other accomplishments include: Being invited by the G4 Network to perform on Freestyle 101. Being awarded "Album Cover of the Week" on VH1.com. Recording alongside Three 6 Mafia on the multi platinum album When the Smoke Clears. Having their own action figure. Appearing as playable characters in, and on the soundtrack of, the "Backyard Wrestling" Playstation Game. Playing the comic relief in the platinum selling movie Big Money Hustlas. Madrox and Monoxide also starred in 2012's Big Money Rustlas. In January 2013, Twiztid played themselves in USA Networks Over/Under. 

Twiztid released their tenth studio album Abominationz in October of 2012. In early 2013 Twiztid left their longtime label Psychopathic Records and were granted their official release. The Demented Duo are constantly working and showing no signs of slowing down, the journey of Madrox & Monoxide has just begun.