Born and raised in Philadelphia, Rundgren began playing guitar as a teenager, going on to found and front The Nazz, the quintessential `60's psychedelic group. In 1969, he left the band to pursue a solo career, recording his debut offering, the legendary Runt. But it was 1972's seminal Something/Anything?, on which he played all the instruments, sang all the vocal parts, and acted as his own producer, that catapulted Todd into the superstar limelight, prompting the press to unanimously dub him 'Rock's New Wunderkind'. It was followed by such landmark LPs as The Hermit of Mink Hollow and the above mentioned A Wizard, A True Star, as well as such hit singles as I Saw The Light, Hello It's Me, Can We Still Be Friends, and Bang The Drum.

In 1974, Todd formed Todd Rundgren’s Utopia (renamed and reconfigured in 1976 as Utopia), an entirely new approach to the concept of interactive musicianship, and embarked on an extensive round of touring and recording. Standout Utopia offerings included Oops! Wrong Planet, Adventures in Utopia, and Oblivion. Along the way, Todd Rundgren’s Utopia combined technical virtuosity and creative passion to create music that initially, for millions, defined the term "progressive rock”, and subsequently, as Utopia, the term “powerpop”.

Rundgren's myriad production projects include albums by Patti Smith, Cheap Trick, Psychedelic Furs, Meat Loaf, XTC, Grand Funk Railroad, and Hall And Oates. Rounding out his reputation as rock's Renaissance Man, Rundgren composed all the music and lyrics for Joe Papp's 1989 Off-Broadway production of Joe Orton's Up Against It (the screenplay commissioned by The Beatles for what was meant to have been their third motion picture). He also has composed the music for the hit film Dumb and Dumber, as well as a number of television series, including Pee Wee’s Playhouse and Crime Story.

In 2009 Rundgren performed his iconic 1973 album A Wizard A True Star in concert in its entirety for the first time ever, and several years later did the same with a double bill: Todd & Healing. He has toured with Ringo Starr as an erstwhile member of the All-Starr Band since 1989, and continues to perform with symphony orchestras both domestically and internationally. In 2018 he toured North America with original Utopians Kasim Sulton and Willie Wilcox for the first time in 33 years. After the release of his long-awaited autobiography The Individualist, he spearheaded the world’s first hybrid concert/book tour highlighting music across his 50-plus-year career.

In 2017 on successive weekends he was awarded honorary doctorates from both the Berklee School of Music and DePauw University.

In 1998 Todd debuted his new PatroNet technology which for the first time allowed fans of a musical artist to subscribe directly to the artist’s musical output via the Internet.